The Rabbit Anti-MC4 Receptor Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to MC4R, and melanocortin 4 receptor. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-MC4 Receptor Antibody has been shown to work in the following applications: Flow Cytometry, and Immunofluorescence.
Description
The melanocortin family comprises the Alpha-, Beta- and Gamma- melanocyte stimulating hormones (MSH) and adrenocorticotrophin. The receptors for these hormones are seven-transmembrane G protein-coupled proteins that activate adenylyl cyclase. Five melanocortin receptors have been cloned and shown to exhibit different affinities and patterns of expression. MC1-R (MSH-R) is expressed in melanocytes and corticoadrenal tissue. MC2-R is the ACTH receptor and is expressed primarily in the adrenal cortex. MC3-R has been found in specific regions of the brain and is also expressed in placenta and gut. MC4-R is expressed primarily in brain, while MC5-R is expressed at low levels in most tissues