MyBioSource.com's Mouse Anti-Complement Factor I Antibody is a Mouse monoclonal antibody. The Mouse Anti-Complement Factor I Antibody was generated using CFI, and Complement factor I as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: FLISA, Immunoassay, and Western Blot.
Description
Complement Factor I is a member of the peptidase S1 family present in the blood plasma. Factor I is an 88kD protein consisting of one polypeptide chain of 35.4kD and one of 27.6kD. Factor I is a serine protease which inactivates complement components C3b and C4b. C3b cleavage requires the presence of cofactors complement component (3b/4b) receptor 1 (CR1), membrane cofactor protein or factor H, while C4b cleavage requires complement component 4 binding protein or CR1. Factor I has no natural inhibitors. Dysfunctional factor I can lead to uncontrolled activation of the alternative complement pathway causing systemic depletion of C3 and lowering levels of factors B and H, resulting in recurrent pyogenic infections. Defects in CFI are also associated with haemolytic uraemic syndrome