MyBioSource.com's IgE/FITC, Rpab Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
IgE, Immunoglobulin E, is an isotype ofantibodyonly found in mammals. IgE is synthesized byplasma cells. Monomers of IgE consist of two heavy chains (epsilon chain) and two light chains, with the epsilon chain containing 4 Ig-like constant domains (Cepsilon1-Cepsilon4). IgE’s main function is immunity to parasites such as helminths like Schistosoma mansoni,Trichinella spiralis, and Fasciola hepatica. IgE is utilized during immune defense against certain protozoan parasites such as Plasmodium falciparum.
IgE also has an essential role in type I hypersensitivity, which manifests in various allergic diseases, such as allergic asthma, most types of sinusitis,allergic rhinitis, food allergies, and specific types of chronic urticaria and atopic dermatitis. IgE also plays a pivotal role in responses to allergens, such as: anaphylactic drugs, bee stings, and antigen preparations used in desensitization immunotherapy. IgE is known to be elevated in various autoimmune disorders such as Lupus(SLE), Rheumatoid Arthritis(RA) & psoriasis, and is theorized to be of pathogenetic importance in RA and SLE by eliciting a hypersensitivity reaction