The Anti-CD27 antibody (DM58), Rabbit mAb from MyBioSource.com is a Rabbit Monoclonal antibody to CD27. This antibody recognizes Human antigen. The Anti-CD27 antibody (DM58), Rabbit mAb has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Flow Cytometry.
Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor