Sortilin Antibody AF2934 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemSortilin Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF2934
NCBI Gene Aliases2900053A11Rik, NT3, Ntsr3, Ntr3, Gp95, NTR3, LDLCQ6
ApplicationsImmunohistochemistry,Western Blot,In vivo assay,Simple Western,Blockade of Receptor-ligand Interaction,Immunocytochemistry
HostGoat
Quantity100 ug (also 25 ug)
TargetSortilin
Conjugate/TagUnconjugated
IsotypeIgG
ReactivityHuman,Mouse,Rat
NCBI Full Gene Namesortilin 1
ClonalityPolyclonal
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse Sortilin, Gly76-Asn753, Accession # Q6PHU5
ConcentrationLYOPH
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
PurityAntigen Affinity-purified

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse Sortilin in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 30% cross-reactivity with recombinant human Sortilin is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitisCell MetabolismMay 6, 2025Fanglin Ma, Miriam Longo, Marica Meroni, Dipankar Bhattacharya, Erika Paolini, Shama Mughal, Syed Hussain, Sumit Kumar Anand, Neha Gupta, Yiwei Zhu, et al.2192606" Rabbit anti-Vps35,Abcam,"Cat# ab10099, RRID:AB_ 296841" Goat anti-sortilin,R&D Systems,"Cat# AF2934, RRID:AB_ 2192424" Donkey anti-rabbit (HRP),Jackson ImmunoResearch Labs,"Cat# 711–035–152,RRID:AB_10015282" Donkey

(2) Neuron-specific gene NSG1 binds to and positively regulates sortilin ectodomain shedding via a metalloproteinase-dependent mechanismThe Journal of biological chemistryDecember 1, 2023Overby M, Serrano-Rodriguez A, Dadras S, Christiansen AK, Ozcelik G, Lichtenthaler SF, Weick JP, Müller HK.

(3) Sortilin Is Upregulated in Osteoarthritis-Dependent Cartilage Calcification and Associated with Cellular SenescenceInternational journal of molecular sciencesAugust 2, 2023Richter E, Lohmann CH, Dell'Accio F, Goettsch C, Bertrand J.

(4) Sortilin Inhibition Protects Neurons From Degeneration in the Diabetic RetinaInvestigative ophthalmology & visual scienceJune 1, 2023Jakobsen TS, Østergaard JA, Kjolby M, Birch EL, Bek T, Nykjaer A, Corydon TJ, Askou AL.diabetic mice was injected intravitreally with 2 µL of 1 mg/mL goat anti-sortilin polyclonal antibody (AF2934, R&D Systems, Minneapolis, MN, USA) and the right eye with 2 µL PBS. Twenty eyes from 10 age-matched

(5) Sortilins in the blood-brain barrier: impact on barrier integrityNeural regeneration researchMarch 1, 2023Toth AE, Nielsen MS.purchased from Sigma-Aldrich (St. Louis, MO, USA). Following antibodies were used: anti-sortilin antibody (AF2934, 1:300; R&D Systems, Minneapolis, MN, USA) and anti-claudin-5 antibody (SAB4502981, 1:300), Alexa Fluor

(6) Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve InjuryFrontiers in cellular neuroscienceJanuary 1, 2022Ulrichsen M, Gonçalves NP, Mohseni S, Hjæresen S, Lisle TL, Molgaard S, Madsen NK, Andersen OM, Svenningsen ÅF, Glerup S, et al.MA5-14520",AB_10979488,1:200,IF Rabbit anti-S100β,"Dako, Z0311",AB_10013383,1:400,IF/WB Goat anti-sortilin,"R&D Systems, AF2934",AB_2192424,1:100,IF "Donkey anti-rabbit IgG, Alexa Fluor 488","Invitrogen, A21206",AB_2535792,1:300,IF "Donkey

(7) ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signalingJournal of cell scienceOctober 15, 2021Asaro A, Sinha R, Bakun M, Kalnytska O, Carlo-Spiewok AS, Rubel T, Rozeboom A, Dadlez M, Kaminska B, Aronica E, et al.against NeuN (Abcam, #ab104224; 1:500), FABP7 (EMD Millipore, #ABN14; 1:200) and sortilin (R&D Systems, #AF2934; 1:200), followed by incubation with fluorophore-conjugated secondary antibodies (conjugated to Alexa

(8) Wnt/β-catenin signaling regulates brain-derived neurotrophic factor release from spinal microglia to mediate HIV₁ gp120-induced neuropathic painMolecular painJanuary 1, 2020Zhou X, Tao L, Zhao M, Wu S, Obeng E, Wang D, Zhang W.(1:1000,CST#80E3), rabbit anti-p75 NGF (1:5000, Abcam#ab52987), goat anti-sortilin (1:1500,R&D Systems#AF2934), goat anti-rabbit IgG H&L (HRP) (1:30,000, Abcam#ab97051), goat anti-mouse IgG H&L (HRP) (1:30,000,

(9) Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic painScience advancesJune 1, 2019Richner M, Pallesen LT, Ulrichsen M, Poulsen ET, Holm TH, Login H, Castonguay A, Lorenzo LE, Gonçalves NP, Andersen OM, et al.(30 gauge) eliciting a Straub tail response (37). Antibodies Anti-sortilin (8 μl) (2 μg per mouse; AF2934, R&D Systems) and normal goat IgG (8 μl) (2 μg per mouse; AB-108-C, R&D Systems), both diluted in sterile

(10) Prions amplify through degradation of the VPS10P sorting receptor sortilinPLoS pathogensJune 1, 2017Uchiyama K, Tomita M, Yano M, Chida J, Hara H, Das NR, Nykjaer A, Sakaguchi S.as follows: rabbit anti-sortilin Abs (12369-1AP, Proteintech, Rosemont, IL), goat anti-sortilin Abs (AF2934, R&D systems, Minneapolis, MN), mouse monoclonal anti-sortilin Ab (clone 48, BD Bioscience, San Jose,

(11) Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutationsNature communicationsMay 25, 2017Zhou X, Sun L, Bracko O, Choi JW, Jia Y, Nana AL, Brady OA, Hernandez JCC, Nishimura N, Seeley WW, et al.

(12) Organ of Corti explants direct tonotopically graded morphology of spiral ganglion neurons in vitroThe Journal of comparative neurologyAugust 1, 2016Smith FL, Davis RL.distribution patterns in synapse cultures. The specificity of anti-Sortilin antibody (R&D Systems Cat# AF2934 RRID:AB_2192424, 1:100 dilution) was examined in liver tissue with siRNAs targeted to the SORT1 gene

(13) Spatiotemporal patterns of sortilin and SorCS2 localization during organ developmentBMC cell biologyMarch 10, 2016Boggild S, Molgaard S, Glerup S, Nyengaard JR.(DAKO, s3023) and kept in the dark at 4 °C. Primary antibodies used were goat α-sortilin (R&D systems, AF2934,1:100), sheep α-SorCS2 (R&D systems, AF4237, 1:50), rabbit α-TTF-1 (Santa Cruz, H-190,1:250), rabbit

(14) Sortilin and SorLA display distinct roles in processing and trafficking of amyloid precursor proteinThe Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 2, 2013Gustafsen C, Glerup S, Pallesen LT, Olsen D, Andersen OM, Nykjær A, Madsen P, Petersen CM.X-100 before incubation with primary antibodies; anti-sortilin/F11 and anti-SorLA/20C11, anti-sortilin/ AF2934 and anti-APP/AF1168 (R&D Systems), anti-TGN46/AHP500 (Adb Serotec), anti-LAMP1/ab24170 (Abcam), anti-neurofilament

(15) Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGFJournal of neurochemistryAugust 1, 2012Kalous A, Nangle MR, Anastasia A, Hempstead BL, Keast JR.(1:500; Chemicon, Cat. No. AB1554, lot 24120100), goat anti-mouse sortilin (1:100; R&D Systems, Cat. No. AF2934, lot VYL01), rabbit anti-rat TrkA (1:100; Upstate Biotech, Lake Placid, NY, USA, Cat. No. 06-574, lot

(16) Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signalingNature neuroscienceJanuary 1, 2011Vaegter CB, Jansen P, Fjorback AW, Glerup S, Skeldal S, Kjolby M, Richner M, Erdmann B, Nyengaard JR, Tessarollo L, et al.

(17) From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locusNatureAugust 5, 2010Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, Li X, Li H, Kuperwasser N, Ruda VM, et al.

(18) Antagonism of p66shc by melanoma inhibitory activityCell death and differentiationAugust 1, 2007Kasuno K, Naqvi A, Dericco J, Yamamori T, Santhanam L, Mattagajasingh I, Yang S, Meyskens FL, Bosserhoff AK, Irani K.

(19) A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modificationAtherosclerosisJanuary 1, 0001"Goettsch C, Hutcheson JD, Hagita S, Rogers MA, Creager MD, Pham T, Choi J, Mlynarchik AK, Pieper B, Kjolby M, et al."sections, after blocking in 4% serum, sections were incubated with an antibody against mouse sortilin [AF2934, 1:20; R&D Systems, Minneapolis, MN, USA], Runx2 [M-70, 1:20, Santa Cruz, Dallas, TX, USA], and or osteocalcin

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Sortilin Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Sortilin Antibody from R&D Systems, a Bio-Techne Brand

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