Anti-IRE1 beta antibody GTX87426 from GeneTex

Product Specs
ItemAnti-IRE1 beta antibody
CompanyGeneTex
Price $419.00Supplier Page
Catalog NumberGTX87426
Conjugate/TagUnconjugated
ReactivityHuman
ApplicationsICC/IF, IHC-P
FormatPBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide
HostRabbit
ClonalityPolyclonal
TargetIRE1 beta
ImmunogenThe antiserum was produced against synthesized peptide derived from human IRE1 beta (841-890)
Quantity100 µg
Antibody TypePrimary Antibodies
PurityPurified by antigen-affinity chromatography
Research AreaCell Biology, Cardiovascular
ConcentrationBatch dependent
IsotypeIgG
Gene NameERN2
Molecular Weight102
NCBI Gene AliasesIRE1-BETA, ERN2, IRE1BETA, IRE1b, IRE2p, endoplasmic reticulum to nucleus signaling 2, hIRE2p, IRE1 beta, IRE2p, hIRE2p, IRE1b
NCBI Full Gene Nameendoplasmic reticulum to nucleus signaling 2

Questions and Answers

Can this antibody be used to study IRE1 beta expression in mouse models of colonic tumors?

Yes, the Anti-IRE1 beta antibody has been utilized in a study involving an azoxymethane and dextran sulfate sodium-induced mouse colonic tumor model, where it was used to evaluate IRE1 beta protein expression through immunohistochemistry. The study found that IRE1 beta expression was significantly decreased in tumor tissues compared to control, indicating its relevance in cancer research ().

What applications is this antibody validated for?

The Anti-IRE1 beta antibody is validated for use in immunocytochemistry, immunofluorescence, and immunohistochemistry on paraffin-embedded sections. This versatility allows researchers to utilize it in various experimental setups to study IRE1 beta in different contexts.

Is this antibody specific to human IRE1 beta, and how was it generated?

Yes, the Anti-IRE1 beta antibody specifically recognizes human IRE1 beta. It was generated using a synthesized peptide derived from the human IRE1 beta protein, ensuring specificity for the target antigen.

What is the significance of IRE1 beta in the context of inflammatory bowel disease and cancer?

IRE1 beta plays a crucial role in the endoplasmic reticulum stress response, which is associated with inflammatory bowel disease and cancer. The downregulation of IRE1 beta has been linked to reduced resistance to inflammation in colon tissues, potentially promoting the development of colonic tumors, as demonstrated in the referenced study ().