The Phospho PKC theta (Y90) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The Phospho PKC theta (Y90) Rabbit Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.:cofactor:Magnesium.:The C1 domain: containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B): is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.:enzyme regulation:Three specific sites; Thr-538 (activation loop of the kinase domain): Ser-676 (turn motif) and Ser-695 (hydrophobic region): need to be phosphorylated for its full activation.:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters: a class of tumor promoters.:This is a calcium-independent: phospholipid-dependent: serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation: but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production.:PTM:Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation.:Belongs to the protein kinase superfamily.:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.:Contains 1 AGC-kinase C-terminal domain.:Contains 1 C2 domain.:Contains 1 protein kinase domain.:Contains 2 phorbol-ester/DAG-type zinc fingers.:subunit:Interacts with TXNL2/PICOT.:tissue specificity:Skeletal muscle: megakaryoblastic cells and platelets.: