The RBL2(Phospho Ser952) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The RBL2(Phospho Ser952) Rabbit Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and: in particular: that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2: leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation: associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.:miscellaneous:G0-restricted expression.:PTM:During G0 and early G1 phase of the cell cycle: phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.:Belongs to the retinoblastoma protein (RB) family.:subunit:Interacts with AATF. Interacts with SUV420H1 and SUV420H2 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4: E2F5: LIN9: LIN37: LIN52: LIN54: MYBL1: MYBL2: RBL1: RBL2: RBBP4: TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9: LIN37: LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1.: