Bioassay Technology Laboratory's Stat5(Phospho-Tyr694) Rabbit Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot.
Description
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors: STAT family members are phosphorylated by the receptor associated kinases: and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands: such as IL2: IL4: CSF1: and different growth hormones. It has been shown to be involved in diverse biological processes: such as TCR signaling: apoptosis: adult mammary gland development: and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL