The Smad1(Phospho Ser214) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen.
Description
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).:PTM:Phosphorylated on serine by BMP type 1 receptor kinase.:PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.:Belongs to the dwarfin/SMAD family.:Contains 1 MH1 (MAD homology 1) domain.:Contains 1 MH2 (MAD homology 2) domain.:subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.:subunit:Interacts with HGS: NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit: CREB-binding protein (CBP): p300: SMURF1: SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1.:tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle.: