Bioassay Technology Laboratory's BAP1(Phospho-Ser592) Rabbit Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot.
Description
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition: the enzyme may be involved in regulation of transcription: regulation of cell cycle and growth: response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS): which involves increased risk of cancers including malignant mesothelioma: uveal melanoma and cutaneous melanoma