The AS160(Phospho-Ser588) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, and Mouse antigen. The AS160(Phospho-Ser588) Rabbit Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein: and contains two phopshotyrosine-binding domains (PTB1 and PTB2): a calmodulin-binding domain (CBD): a Rab-GTPase domain: and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4): important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane: suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin: this protein is phosphorylated: dissociates from GLUT4 vesicles: resulting in increased GLUT4 at the cell surface: and enhanced glucose transport. Ph