The ATR(Phospho-Thr1989) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The ATR(Phospho-Thr1989) Rabbit Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
The protein encoded by this gene belongs the PI3/PI4-kinase family: and is most closely related to ATM: a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3: a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1: checkpoint proteins RAD17: and RAD9: as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported: however: its full length nature is not known. Transcript variants utilizing alternative polyA sites exist