The TRAF2(Phospho-Ser11) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, and Mouse antigen. The TRAF2(Phospho-Ser11) Rabbit Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with: and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors: and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs): and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD: a TNF receptor associated apoptotic signal transducer: ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1: an apoptosis inhibitor possessing ubiquitin ligase activity: can unbiquitinate and induce the degradation of this pro