Bioassay Technology Laboratory's Rad50(Phospho-Ser635) Rabbit Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot.
Description
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50: a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein: cooperating with its partners: is important for DNA double-strand break repair: cell cycle checkpoint activation: telomere maintenance: and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder