The Histone H2A.Z (Acetyl Lys14) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The Histone H2A.Z (Acetyl Lys14) Rabbit Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin: limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation: DNA repair: DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones: also called histone code: and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.:mass spectrometry:Monoisotopic: not modified PubMed:16457589:PTM:Acetylated on Lys-5: Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.:PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.:PTM:Not phosphorylated.:Belongs to the histone H2A family.:subunit:The nucleosome is a histone octamer containing two molecules each of H2A: H2B: H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.: