Bioassay Technology Laboratory's Centaurin-beta 1 Rabbit Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Western Blot.
Description
PH domain binds phospholipids including phosphatidic acid: phosphatidylinositol 3-phosphate: phosphatidylinositol 3:5-bisphosphate (PIP2) and phosphatidylinositol 3:4:5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes.:enzyme regulation:GAP activity stimulated by phosphatidylinositol 4:5-bisphosphate (PIP2) and phosphatidic acid.:GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.:miscellaneous:Cells overexpressing ACAP1 show an accumulation of ITGB1 in recycling endosomes and inhibition of stimulation-dependent cell migration. Cells with reduced levels of ACAP1 or AKT1 and AKT2 show inhibition of stimulation-dependent cell migration. Cells overexpressing ACAP1 and PIP5K1C show formation of tubular structures derived from endosomal membranes.:PTM:Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1: export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.:Contains 1 Arf-GAP domain.:Contains 1 BAR domain.:Contains 1 PH domain.:Contains 3 ANK repeats.:subunit:Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1.:tissue specificity:Highest level in lung and spleen. Low level in heart: kidney: liver and pancreas.: