The HDAC1 (Acetyl Lys220) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The HDAC1 (Acetyl Lys220) Rabbit Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A: H2B: H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation: cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.:PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.:PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.:Belongs to the histone deacetylase family. Type 1 subfamily.:subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1: HDAC2: RBBP4 and RBBP7. The core complex associates with MTA2: MBD2: MBD3: MTA1L1: CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex: or with SIN3: SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1: HDAC2: HMG20B/BRAF35: AOF2/LSD1: RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2: ZNF217: ZMYM3: GSE1 and GTF2I. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with BCOR: BRMS1L: DAXX: DNMT1: EP300: HCFC1: NFE4: PCAF: PHB2: MIER1: KDM4A: MINT: NRIP1: PRDM6: RERE: SETDB1: SUV39H1: TGIF: TGIF2: UHRF1: UHRF2 and ZNF541. Interacts with the non-histone region of H2AFY. Interacts with HDAC9. Component of a mSin3A corepressor complex that contains SIN3A: SAP130: SUDS3/SAP45: ARID4B/SAP180: HDAC1 and HDAC2. Interacts with BANP: CBFA2T3 and KDM5B. Interacts with SAP30L. Interacts with E4F1. Interacts with KFL1 (By similarity). Interacts with SV40 large T antigen.:tissue specificity:Ubiquitous: with higher levels in heart: pancreas and testis: and lower levels in kidney and brain.: