The M-CSF Receptor(Phospho-Tyr546) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, and Mouse antigen. The M-CSF Receptor(Phospho-Tyr546) Rabbit Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
The protein encoded by this gene is the receptor for colony stimulating factor 1: a cytokine which controls the production: differentiation: and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants