The Stat2 (Acetyl Lys384) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, and Rat antigen. The Stat2 (Acetyl Lys384) Rabbit Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors: Jak kinases (TYK2 and JAK1) are activated: leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize: associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor: that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes: which drive the cell in an antiviral state.:PTM:Tyrosine phosphorylated in response to IFN-alpha.:Belongs to the transcription factor STAT family.:Contains 1 SH2 domain.:subcellular location:Translocated into the nucleus upon activation by IFN-alpha/beta.:subunit:Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein.: