The GPX2 Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The GPX2 Rabbit Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
The protein encoded by this gene belongs to the glutathione peroxidase family: members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione: and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates: which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human): is localized in the cytoplasm: and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein: containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon: which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure: designated the Sec insertion sequence (SECIS) element: that is necessary for the recognition of UGA as a Sec codon: rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene