Bioassay Technology Laboratory's Shc(Phospho-Tyr317) Rabbit Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot.
Description
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways: the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms: p52Shc and p46Shc: link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms: p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene