Bioassay Technology Laboratory's ER alpha (Acetyl Lys303) Rabbit Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Western Blot.
Description
Composed of three domains: a modulating N-terminal domain: a DNA-binding domain and a C-terminal steroid-binding domain.:Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.:online information:Estrogen receptor entry:polymorphism:Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density: disrutption of bone microarchitecture: and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.:PTM:Glycosylated; contains N-acetylglucosamine: probably O-linked.:PTM:Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.:Belongs to the nuclear hormone receptor family.:Belongs to the nuclear hormone receptor family. NR3 subfamily.:Contains 1 nuclear receptor DNA-binding domain.:subunit:Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3: NCOA5 and NCOA6 coactivators: leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2: PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2: FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol.: