Bioassay Technology Laboratory's APOB Rabbit Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Western Blot.
Description
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms: apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single: very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA): resulting in the creation of a stop codon: and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia: normotriglyceridemic hypobetalipoproteinemia: and hypercholesterolemia due to ligand-defective apoB: diseases affecting plasma cholesterol and apoB levels