The Stat4 Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The Stat4 Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, Precipitation, ELISA, Immunohistochemistry, Immunohistochemistry - fixed, Immunoprecipitation, and Western Blot.
Description
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein