TAK1(Phospho-Ser412) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP): and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1: this protein forms a kinase complex including TRAF6: MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK: MAP2K4/MKK4: and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported