Bioassay Technology Laboratory's HIF-1 alpha (Acetyl Lys532) Rabbit Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, and Western Blot.
Description
Contains two independent C-terminal transactivation domains: NTAD and CTAD: which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID).:Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes: including: erythropoietin: glucose transporters: glycolytic enzymes: vascular endothelial growth factor: and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization: tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-