Chk2(Phospho-Ser19) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory

In response to DNA damage and replication blocks: cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated: the encoded protein is known to inhibit CDC25C phosphatase: preventing entry into mitosis: and has been shown to stabilize the tumor suppressor protein p53: leading to cell cycle arrest in G1. In addition: this protein interacts with and phosphorylates BRCA1: allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome: a highly penetrant familial cancer phenotype usually associated with inherited mutati