Integrin alphaIIb Rabbit Polyclonal Antibody from Bioassay Technology Laboratory

This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system: by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders: which are characterized by a failure of platelet aggregation: including Glanzmann thrombasthenia