The TOP2A(Phospho Ser1213) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen.
Description
Catalytic activity:ATP-dependent breakage: passage and rejoining of double-stranded DNA.:enzyme regulation:Specifically inhibited by the intercalating agent amsacrine.:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.:miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils: whereas prokaryotic enzymes relax only negative supercoils.:PTM:Phosphorylation has no effect on Catalytic activity.:Belongs to the type II topoisomerase family.:subcellular location:Generally located in the nucleoplasm.:subunit:Homodimer. Interacts with COPS5.: