Bioassay Technology Laboratory's Raf-1(Phospho Ser296) Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K): which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated: the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2: which in turn phosphorylate to activate the serine/threonine specific protein kinases: ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle: apoptosis: cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2