DDR1(Phospho-Tyr792) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth: differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain: and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells: particularly in the kidney: lung: gastrointestinal tract: and brain. In addition: it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene