The TLK1(Phospho Ser764) Rabbit Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The TLK1(Phospho Ser764) Rabbit Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.:cofactor:Magnesium.:enzyme regulation:Cell-cycle regulated: maximal activity in S-phase. Inactivated by phosphorylation at Ser-743: potentially by CHK1.:Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23: augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro: phosphorylates histone H3 at 'Ser-10'.:Belongs to the protein kinase superfamily.:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.:Contains 1 protein kinase domain.:subunit:Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B.:tissue specificity:Widely expressed. Present in fetal placenta: liver: kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.: