The DUSP4 Polyclonal Antibody from Bioassay Technology Laboratory is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The DUSP4 Polyclonal Antibody has been shown to work in the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK: SAPK/JNK: p38): which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases: different tissue distribution and subcellular localization: and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1: ERK2 and JNK: is expressed in a variety of tissues: and is localized in the nucleus. Two alternatively spliced transcript variants: encoding distinct isoforms: have been obser