Bioassay Technology Laboratory's Raf-B(Phospho Ser446) Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: EIA, Immunoassay, ELISA, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway: which affects cell division: differentiation: and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome: a disease characterized by heart defects: mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers: including non-Hodgkin lymphoma: colorectal cancer: malignant melanoma: thyroid carcinoma: non-small cell lung carcinoma: and adenocarcinoma of lung. A pseudogene: which is located on chromosome X: has been identified for this gene