Bioassay Technology Laboratory's UBA3 Rabbit Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot.
Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes: or E1s: ubiquitin-conjugating enzymes: or E2s: and ubiquitin-protein ligases: or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1: an amyloid beta precursor protein binding protein: to form a heterodimer: and then the enzyme complex activates NEDD8: a ubiquitin-like protein: which regulates cell division: signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene