The Anti-FBXO27 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-FBXO27 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunocytochemistry, and Immunofluorescence.
Description
F-box proteins are receptors for substrates in the SCF (SKP1-CUL1-F-box protein-RBX1) ubiquitin ligase complex. F-box proteins belong to a large protein family comprised of ~70 proteins in humans. Among these are FBXO2 and FBXO6, which bind to glycoproteins modified with high-mannose N-glycans found in the ER. FBXO27, as well as FBXO2 and FBXO6, bind to glycoproteins modified with high-mannose N-glycans. However, FBXO27 has also been reported to bind some glycoproteins modified with complex-type N-glycans, suggesting that the SCF complex containing FBXO27 has the ability to ubiquitinate glycoproteins that have transited from the ER to other organelles or the plasma membrane