The Anti-TBK1 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-TBK1 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
TANK-binding kinase 1 (TBK1) is an important serine/threonine-protein kinase that mediates phosphorylation and nuclear translocation of IRF3, which contributes to the induction of type I interferons (IFNs) in the innate antiviral response. TBK1 is a noncanonical IkappaB kinase family member that regulates the innate immune response. Misregulation of TBK1 activity can promote inflammatory disorders and oncogenesis; therefore, TBK1 inhibitors are considered a promising therapy for inflammation and cancer. In mammals, TBK1 spliced isoform negatively regulates the virus-triggered IFN-beta signaling pathway by disrupting the interaction between retinoic acid-inducible gene I (RIG-I) and mitochondria antiviral-signaling protein (MAVS). TBK1 plays a crucial role as the hub for many innate immune signaling pathways. Due to its key function in maintaining homeostasis of the immune system, cell survival, and proliferation, TBK1 activity is tightly regulated