MyBioSource.com's Anti-SHMT1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Immunohistochemistry - fixed.
Description
The serine hydroxymethyltransferase (SHMT1) is the key enzyme in the folate metabolic pathway to provide a one-carbon unit that plays an important role in biosynthesis and is known to contribute to the development of hypertension. SHMT1 provides one-carbon units necessary for embryogenesis and defects in one-carbon production result in specific pathological conditions during pregnancy. SHMT1 regulates the partitioning of folate-activated one-carbons between thymidylate and S-adenosylmethionine biosynthesis. Therefore, changes in SHMT1 expression enable the determination of the specific contributions made by thymidylate and S-adenosylmethionine biosynthesis to CRC risk. SHMT1 plays critical roles in human cancers including lung cancer, ovarian cancer, and intestinal cancer. An SNP in SHMT1 C1420T may affect the procession of biosynthesis and finally influence cancer occurrence