The Rabbit Anti-RABGAP1L Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Rabbit Anti-RABGAP1L Antibody has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
RabGAP1L belongs to the Tre2-Bub2-Cdc16 (TBC) domain-containing family of Rab-specific GTPase-activating proteins (TBC/RabGAPs), which regulate intracellular membrane trafficking in multiple cellular contexts. Specifically, RabGAP1L, via a catalytic site on the TBC domain, inactivates Rab22A by promoting its GDP-bound configuration. In addition, RabGAP1L contains an N-terminal phosphotyrosine-binding (PTB) domain and a kinesin-like domain of unknown function. RABGAP1L expression was upregulated in esophageal squamous cell carcinomas compared with matched normal esophageal epithelial tissue. In particular, RABGAP1L expression was upregulated in esophageal tumors showing nodal invasion