MyBioSource.com's Anti-CTNNA3 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot. The Anti-CTNNA3 Antibody, Rabbit Polyclonal was generated using catenin alpha 3, and CTNNA3 as the antigen and it reacts with Human.
Description
CTNNA3 (alpha-T-catenin) is imprinted with a preferential monoallelic expression of the maternal allele in placental tissue. Hepatocellular carcinoma (HCC) is a common and leading cause of death worldwide. Here, we identified that a cell-cell adhesion gene, CTNNA3, is a tumor suppressor in HCC. CTNNA3 inhibited the proliferation, migration and invasion of HCC cell lines. In these cells, CTNNA3 inhibited Akt signal, and in turn decreased the proliferating cell nuclear antigen (PCNA) and the matrix metallopeptidase MMP-9, and increased the cell cycle inhibitor p21(Cip1/Waf1). Meanwhile, CTNNA3 is inhibited by miR-425 in HCC. The alpha E-catenin is a well-known invasion suppressor. A recently described novel alpha-catenin, i.e. alpha T-catenin (CTNNA3), shows related functions being necessary for the formation of cell-cell adhesion complexes. The gene dosage compensation of CTNNA3 and p57KIP2 in the placenta shares a conserved regulatory mechanism that correlates with an early step in trophoblast determination, i.e. differentiation into villus or extravillous trophoblast. Alpha-T-Catenin (CTNNA3) is a key protein of the adherens junctional complex in epithelial cells playing a crucial role sin cellular adherence