MyBioSource.com's Rabbit Anti-SELENBP1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Selenium-binding protein 1 (Selenbp1), an Nkx2-1 effector that limits phenotypes associated with lung cancer growth and metastasis, was investigated further. Loss-and gain-of-function approaches demonstrate that Nkx2-1 is required and sufficient for Selenbp1 expression in lung adenocarcinoma cells. SELENBP1 expression is reduced markedly in many types of cancers and low SELENBP1 expression levels are associated with poor patient prognosis. Selenbp1 is suggested to play a role in tumor suppression and may be involved in the toxicity produced by dioxin, an activator of aryl hydrocarbon receptors (AhR). SELENBP1 is associated with cellular redox and thiol homeostasis in several respects, including its established role as a methanethiol oxidase that is involved in the degradation of methanethiol, a methionine catabolite, generating hydrogen sulfide (H2S) and hydrogen peroxide (H2O2)