The Anti-NRBP2 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody to NRBP2. This antibody recognizes Human antigen. The Anti-NRBP2 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
NRBP2 (Nuclear Receptor Binding Protein 2) is a gene under strong regulation during cerebellar differentiation. Being a pseudokinase, NRBP2 lacks 7 out of 15 residues of the kinase domain. Although devoid of catalytic activity, pseudokinases are increasingly viewed as components of signaling pathways. NRBP2 has a 59% amino acid sequence similarity to nuclear receptor binding protein 1 (NRBP1) a pseudokinase identified as a tumor suppressor and needed for terminal differentiation of intestinal progenitor cells. Besides, NRBP2 also plays an important role in the tumor progression and chemotherapeutic resistance of hepatocellular carcinoma. Downregulation of NRBP2 is a feature of medulloblastoma contributing to tumor fitness