MyBioSource.com's Anti-TAX1BP3 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot.
Description
Tax interacting protein 1 (TIP-1, also known as Tax1BP3) is a molecular target that enables the selective binding of the HVGGSSV peptide within irradiated xenograft tumors. Genetic analysis revealed a homozygous missense mutation in TAX1BP3, which encodes a small PDZ domain-containing protein implicated in the regulation of the Wnt/beta-catenin signaling pathway, as the causative mutation. The mutation affects a conserved residue located at the core of the TAX1BP3 binding pocket and is predicted to impair the nature of a crucial hydrophobic patch, thereby interrupting the structure and stability of the protein, and its ability to interact with other proteins. TAX1BP3 is highly expressed in the heart and brain. Tax1bp3 inhibited the proliferation of colon cancer cells by antagonizing the transcriptional activity of beta-catenin