The Rabbit Anti-ARHGEF26 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Rabbit Anti-ARHGEF26 Antibody has been shown to work in the following applications: Immunocytochemistry, and Immunofluorescence.
Description
GTPase exchange factors (RhoGEFs) can be distributed into two families: the Dbl-related and the Dock-related RhoGEFs. The Dbl (diffuse B-cell lymphoma) family counts 71 members and there are 11 proteins in the Dock (Dedicator Of CytoKinesis) family. They activate RhoGTPase via their catalytic domain called the DH domain for the Dbl family or the DHR2 domain for the Dock family. The RhoGEFs are multidomain proteins: their catalytic domain is accompanied by various functional domains that can mediate the association of the GEF with membrane receptors or lipids for instance, or that provide the GEF with other enzymatic activities, such as kinase, phosphatase, or even GEF or GAP function towards other Ras-like GTPases. RhoGEFs activate their target Rho GTPases in response to different signals, usually transmitted from the extracellular medium by membrane receptors. This results in local and temporal regulation of the activation of Rho GTPases