MyBioSource.com's Anti-SRSF10 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, and Immunofluorescence.
Description
Splicing factor SRSF10 is known to function as a sequence-specific splicing activator that is capable of regulating alternative splicing both in vitro and in vivo. SRSF10 plays a crucial role in cell survival under stress conditions. SRSF10 modulates the alternate terminator of interleukin-1 receptor accessory protein exon 13 to increase the production of the membrane form of interleukin-1 receptor accessory protein. SRSF10-mediated mIL1RAP upregulates the expression of the "don't eat me" signal CD47 to inhibit macrophage phagocytosis by promoting nuclear factor-kappaB activation, which is pivotal in inflammatory, immune, and tumorigenesis processes. SRSF10-mIL1RAP-CD47 axis could be an attractive therapeutic target for the treatment of cervical cancer. SRSF10 is a key regulator of BCLAF1 pre-mRNA splicing and the maintenance of oncogenic features in human colon cancer cells