MyBioSource.com's Anti-PPP2R5E Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunohistochemistry - fixed, Immunoprecipitation, and Western Blot.
Description
Single nucleotide polymorphism in B56epsilon (PPP2R5E), a B56 family regulatory subunit of PP2A, is associated with human soft tissue sarcoma. This raises the possibility that B56epsilon is involved in tumorigenesis and plays important role in regulating apoptosis. The PPP2R5E gene is identified as harboring genetic variants that can affect human cancer and are possibly under evolutionary selection pressure. PPP2R5E is downregulated by miR-23a and induces cell growth inhibition and apoptosis in gastric cancer cells. PPP2R5E is identified as a new target of miR-23a, and overexpression of PPP2R5E reversed the negative effects of miR-23a. PPP2R5E interacts with MTCL1. Depletion of PPP2R5E reduced the abundance of MTCL1 abundance, whereas exogenous expression of PPP2R5E increased endogenous MTCL1. The PPP2R5E phosphatase may contribute to microtubule organization by stabilizing MTCL1