MyBioSource.com's Anti-SLC43A1 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
L-type amino acid transporter 3 (LAT3/SLC43A1), mediates uptake of large neutral branched chain amino acids (BCAA) including leucine. LAT3, encoded by the gene SLC43A1, was originally named prostate cancer overexpressed gene 1 (POV1), and was later identified as a major uniporter of leucine, isoleucine, valine, phenylalanine and methionine. Human LAT3 is predicted to contain 12 transmembrane (TM) domains. A long intracellular loop between transmembrane domains 6 and 7 contains putative serine phosphorylation sites and a tyrosine phosphorylation site. LAT3 protein expression is high in primary and recurrent prostate cancer, driven by direct androgen receptor (AR) transcription. SLC43A1 is related to neutral amino acid transmembrane transporter activity and L-amino acid transmembrane transporter activity. An important paralog of this gene is SLC43A2