MyBioSource.com's Anti-UGT1A6 Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
The UDP glucuronosyltransferase 1A6 (UGT1A6) protein is expressed predominantly in the liver and metabolizes small phenolic drugs including acetaminophen, salicylates, and many beta-blockers. The metabolic enzyme of UGT1A6 has been considered to metabolize propofol intra-or extrahepatically. Genetic variants in the UGT1A6 enzyme are associated with delayed aspirin metabolism and greater chemopreventive efficacy. Variant genotypes of UGT1A6 associated with decreased metabolic activity have been associated with an enhanced protective effect of aspirin on the development of colorectal adenomas. The UGT1A6 and cytochrome P450 2C9 (CYP2C9) enzymes participate in the metabolism of nonsteroidal anti-inflammatory drugs, endogenous substances, and carcinogens. Functional polymorphisms of UGT1A6 (T181A and R184S) and CYP2C9 (R144C and I359L) have been reported to modify the protective effect of aspirin on colorectal adenoma risk