The Anti-ZBTB1 Antibody, Rabbit Polyclonal from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The Anti-ZBTB1 Antibody, Rabbit Polyclonal has been shown to work in the following applications: Western Blot.
Description
Zinc Finger and BTB domain-containing protein 1 (Zbtb1) is a transcription factor that prevents DNA damage and p53-mediated apoptosis in replicating immune progenitors, affecting lymphoid as well as myeloid development when hematopoietic progenitors are in competition in mixed bone marrow chimeras. Zbtb1-deficient mice do not have an apparent myeloid deficiency. Zbtb1 is essential for the development of T-cells. A point mutation in the BTB domain of Zbtb1 termed "ScanT", as well as Zbtb1 deficiency, leads to complete absence of T-cells. ZBTB1 is uniquely essential under asparagine deprivation. ZBTB1 knockout cells are unable to synthesize asparagine due to reduced expression of asparagine synthetase (ASNS), the enzyme responsible for asparagine synthesis